Author

S. M. Ekkel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Approach:experimental assay· 2 Research Focus:protein structure prediction· 2 Organism:human· 1

Frequent Co-Authors

B. A. Spicer· 2 shared C. Bayly-Jones· 2 shared H. Venugopal· 2 shared J. C. Whisstock· 2 shared M. A. Dunstone· 2 shared A. W. Hodel· 1 shared B. H. T. Ho· 1 shared B. W. Hoogenboom· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiochemistry

B. A. Spicer

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2 papers

Recent·Most cited

The neoepitope of the complement C5b-9 Membrane Attack Complex is formed by proximity of adjacent ancillary regions of C9

C. Bayly-Jones, B. H. T. Ho, C. Lau, E. W. W. Leung, L. D'Andrea, C. J. Lupton, S. M. Ekkel, H. Venugopal, J. C. Whisstock, T. E. Mollnes, B. A. Spicer, M. A. Dunstone

This study identifies the discontinuous quaternary neoepitope of the C9 protein in the complement C5b-9 complex using cryo-EM, revealing its formation through adjacent domains without major conformational changes.

bioRxiv · Jul 6, 2022 · PreprintBiochemistry

The structure of Macrophage Expressed Gene-1, a phagolysosome immune effector that is activated upon acidification.

S. S. Pang, C. Bayly-Jones, M. Radjainia, B. A. Spicer, R. H. P. Law, A. W. Hodel, S. M. Ekkel, P. J. Conroy, G. Ramm, H. Venugopal, P. I. Bird, B. W. Hoogenboom, I. Voskoboinik, Y. Gambin, E. Sierecki, , J. C. Whisstock

This paper determines the structure of MPEG-1, showing it forms a pre-pore complex and can perforate membranes under acidic conditions.

bioRxiv · Mar 17, 2019 · PreprintBiochemistry