Total Chemical Synthesis of Glycosylated TREM2 Ectodomain
G. Wijegunawardena, E. Castillo, B. Henrickson, R. Davis, C. Condello, H. Wu
This paper presents a total chemical synthesis of the TREM2 ectodomain, demonstrating its functional effects on microglial cells and highlighting the importance of glycosylation for thermal stability.
bioRxiv · Apr 14, 2023Biochemistry