BiochemistrybioRxiv
Total Chemical Synthesis of Glycosylated TREM2 Ectodomain
G. Wijegunawardena, E. Castillo, B. Henrickson…·H. Wu
This paper presents a total chemical synthesis of the TREM2 ectodomain, demonstrating its functional effects on microglial cells and highlighting the importance of glycosylation for thermal stability.
DOI 10.1021/acschemneuro.3c00257