A Mechanistic Reinterpretation of Fast Inactivation in Voltage-Gated Na+ Channels
Y. Liu, B. I. Pinto, C. Z. Bassetto, F. Bezanilla
The paper reinterprets the mechanism of fast inactivation in voltage-gated Na+ channels using ionic and gating current data, identifying two hydrophobic rings at the bottom of S6 as the inactivation gate.
bioRxiv · Apr 27, 2023Biophysics