Author

B. J. Ryckman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

E. P. Schultz· 3 shared J.-M. Lanchy· 3 shared Q. Yu· 3 shared C. Stegmann· 2 shared J. P. Kamil· 2 shared L. Z. Day· 2 shared D. Amendola· 1 shared D. Maione· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersMicrobiology

E. P. Schultz

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4 papers

Recent·Most cited

Mutagenesis of human cytomegalovirus glycoprotein L disproportionately disrupts gH/gL/gO over gH/gL/pUL128-131.

E. P. Schultz, Q. Yu, C. Stegmann, L. Z. Day, J.-M. Lanchy, B. J. Ryckman

This study shows that mutations in the gL subunit of HCMV disproportionately affect gH/gL/gO function compared to gH/gL/pUL128-131, revealing functional differences between the two complexes.

bioRxiv · Apr 9, 2021Microbiology

The human cytomegalovirus protein UL116 interacts with the viral ER resident glycoprotein UL148 and promotes the incorporation of gH/gL complexes into virions

M. N. A. Siddiquey, E. P. Schultz, Q. Yu, D. Amendola, G. Vezzani, d. yu, D. Maione, J.-M. Lanchy, B. J. Ryckman, M. Merola, J. P. Kamil

This study identifies UL116 as a chaperone for gH that promotes gH/gL complex expression and virion incorporation, interacting with UL148 to support viral entry mechanisms.

bioRxiv · Nov 17, 2020Microbiology

Polymorphisms in Human Cytomegalovirus gO Exert Epistatic Influences on Cell-Free and Cell-To-Cell Spread, and Antibody Neutralization on gH Epitopes.

L. Z. Day, C. Stegmann, E. P. Schultz, J.-M. Lanchy, Q. Yu, B. J. Ryckman

This study shows how variations in the gO protein of HCMV affect viral spread and antibody neutralization, with effects influenced by genetic background.

Journal of Virology · Mar 31, 2020Peer-reviewedMicrobiology

Expression levels of glycoprotein O (gO) vary between strains of human cytomegalovirus, influencing the assembly of gH/gL complexes and virion infectivity.

L. Zhang, M. Zhou, R. Stanton, J. P. Kamil, B. J. Ryckman

This study shows that differences in gO and UL128-131 expression levels between HCMV strains affect gH/gL complex assembly and virion infectivity, with UL128-131 repression having a stronger impact on infectivity than gO expression.

bioRxiv · Apr 11, 2018Microbiology