Author

J. P. Kamil

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 12

Signature Assays, Organisms & Methods

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Approach:experimental assay· 12 Organism:human· 11 Research Focus:host-pathogen & immune response· 9 Assay:proteomics· 7 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1

Frequent Co-Authors

H. Zhang· 6 shared A. J. Domma· 4 shared M. N. A. Siddiquey· 4 shared C. C. Nguyen· 3 shared F. Goodrum· 3 shared B. J. Ryckman· 2 shared D. Collins-McMillen· 2 shared N. J. Moorman· 2 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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6 shared papersMicrobiology

H. Zhang

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12 papers

Recent·Most cited

Human cytomegalovirus attenuates AKT activity by destabilizing insulin receptor substrate proteins

A. J. Domma, F. Goodrum, N. J. Moorman, J. P. Kamil

This study shows that human cytomegalovirus (HCMV) inactivates AKT by using UL38 to degrade IRS1, which is necessary for AKT activation during infection.

bioRxiv · Apr 17, 2023Microbiology

A collaborative approach to improving representation in viral genomic surveillance

P. Kim, A. Y. Kim, J. J. Newman, E. Cella, T. C. Bishop, P. J. Huwe, O. N. Uchakina, R. J. McKallip, V. L. Mack, M. P. Hill, I. V. Ogungbe, O. Adeyinka, S. Jones, G. Ware, J. L. Carroll, , J. P. Kamil

This paper develops a collaborative genomic surveillance model to improve representation in rural and minority communities, generating over 1,000 SARS-CoV-2 genomes and identifying new variants.

bioRxiv · Oct 19, 2022 · PreprintMicrobiology

The AKT Forkhead box O transcription factor axis regulates human cytomegalovirus replication

H. Zhang, A. J. Domma, F. Goodrum, N. Moorman, J. P. Kamil

This study shows that HCMV inactivates AKT to promote FOXO3a nuclear localization, which is required for efficient viral replication.

bioRxiv · Apr 14, 2022Microbiology

The human cytomegalovirus protein UL116 interacts with the viral ER resident glycoprotein UL148 and promotes the incorporation of gH/gL complexes into virions

M. N. A. Siddiquey, E. P. Schultz, Q. Yu, D. Amendola, G. Vezzani, d. yu, D. Maione, J.-M. Lanchy, B. J. Ryckman, M. Merola, J. P. Kamil

This study identifies UL116 as a chaperone for gH that promotes gH/gL complex expression and virion incorporation, interacting with UL148 to support viral entry mechanisms.

bioRxiv · Nov 17, 2020Microbiology

Alpha-1-antitrypsin and its variant-dependent role in COVID-19 pathogenesis

C. S. Stevens, K. Y. Oguntuyo, S. Kowdle, A. Gowlikar, M. N. Siddiquey, J. A. Acklin, G. Haas, R. M. Schilke, M. D. Woolard, H. Zhang, L. Brambilla, S. Ikegame, C.-t. Hung, J. K. Lim, R. W. Cross, , B. Lee

This study investigates the role of alpha-1-antitrypsin in inhibiting SARS-CoV-2 entry and shows variant-dependent effects on its ability to block different viral strains.

bioRxiv · Aug 14, 2020 · PreprintMicrobiology

FOXO Transcription Factors Activate Alternative Major Immediate Early Promoters to Induce Human Cytomegalovirus Reactivation

A. E. Hale, D. Collins-McMillen, E. M. Lenarcic, J. P. Kamil, F. Goodrum, N. J. Moorman

This study identifies FOXO transcription factors as critical for activating alternative MIE promoters during HCMV reactivation from latency in hematopoietic progenitor cells.

Proceedings of the National Academy of Sciences · Jul 21, 2020Peer-reviewedMicrobiology

ER reorganization and intracellular retention of CD58 are functionally independent properties of the human cytomegalovirus ER resident glycoprotein UL148

C. C. Nguyen, A. J. Domma, H. Zhang, J. P. Kamil

This study shows that ER reorganization and CD58 retention by HCMV UL148 are independent functions, as mutations affecting one do not impact the other.

bioRxiv · Aug 27, 2019Microbiology

A cytomegalovirus immunevasin triggers integrated stress response-dependent reorganization of the endoplasmic reticulum.

H. Zhang, C. Read, C. C. Nguyen, M. N. A. Siddiquey, C. Shang, C. M. Hall, J. von Einem, J. P. Kamil

This paper shows that HCMV's UL148 protein reorganizes the ER via the integrated stress response, affecting viral infectivity and immune evasion.

bioRxiv · Aug 17, 2019 · PreprintMicrobiology

Alternative Promoters Drive Human Cytomegalovirus Reactivation from Latency

D. Collins-McMillen, M. Rak, J. Buehler, S. Igarashi-Hayes, J. P. Kamil, N. Moorman, F. D. Goodrum

This study identifies alternative promoters that drive HCMV reactivation from latency, challenging the previous understanding that the MIEP is the primary driver.

bioRxiv · Dec 1, 2018Microbiology

The human cytomegalovirus ER resident glycoprotein UL148 activates the unfolded protein response

M. N. A. Siddiquey, H. Zhang, C. C. Nguyen, A. J. Domma, J. P. Kamil

This paper identifies UL148, a human cytomegalovirus glycoprotein, as an activator of the unfolded protein response (UPR) in both infected and uninfected cells.

bioRxiv · May 23, 2018Microbiology

Human cytomegalovirus tropism modulator UL148 interacts with SEL1L, a cellular factor that governs ER-associated degradation of the viral envelope glycoprotein, gO

C. Nguyen, M. N. A. Siddiquey, H. Zhang, J. P. Kamil

This study identifies UL148's interaction with SEL1L, showing it stabilizes gO by modulating ERAD, thereby influencing HCMV tropism.

bioRxiv · Apr 19, 2018Microbiology

Expression levels of glycoprotein O (gO) vary between strains of human cytomegalovirus, influencing the assembly of gH/gL complexes and virion infectivity.

L. Zhang, M. Zhou, R. Stanton, J. P. Kamil, B. J. Ryckman

This study shows that differences in gO and UL128-131 expression levels between HCMV strains affect gH/gL complex assembly and virion infectivity, with UL128-131 repression having a stronger impact on infectivity than gO expression.

bioRxiv · Apr 11, 2018Microbiology