Non-cell autonomous cardiomyocyte regulation complicates gene supplementation therapy for LMNA cardiomyopathy
Y. Sun, C. Guo, Z. Chen, J. Lin, L. Yang, Y. Zhang, C. Wu, D. Zhao, B. Jardin, W. Pu, M. Zhao, E. Dong, X. Hu, S. Zhang, Y. Guo
This study shows that gene supplementation for LMNA cardiomyopathy is ineffective when targeting cardiomyocytes alone, as non-cell autonomous effects dominate, suggesting alternative therapeutic targets.
bioRxiv · Jul 18, 2023 · PreprintCell Biology