Patient-Derived Orthotopic Xenografts and Cell Lines from Pediatric High-Grade Glioma Recapitulate the Heterogeneity of Histopathology, Molecular Signatures, and Drug Response
C. He, K. Xu, X. Zhu, P. S. Dunphy, B. Gudenas, W. Lin, N. Twarog, L. D. Hover, C.-H. Kwon, L. H. Kasper, J. Zhang, X. Li, J. Dalton, B. Jonchere, K. S. Mercer, , S. J. Baker
The paper establishes patient-derived orthotopic xenograft models and cell lines from pediatric high-grade glioma that replicate histopathology, molecular signatures, and drug response, providing a resource for research.
bioRxiv · Dec 6, 2020 · PreprintCancer Biology