X. Zhu

Dynamic Regulation of Innate Lymphoid Cell Development During Ontogeny

This study investigates the developmental changes in innate lymphoid cell (ILC) subsets using scRNA-seq and differentiation assays, revealing distinct regulatory programs in fetal and adult stages.

MoLst8 regulates autophagy and lipid homeostasis in Magnaporthe oryzae

This study investigates the role of MoLst8 in autophagy and lipid homeostasis in Magnaporthe oryzae, showing its positive regulation of TORC1 and disruption of lipid metabolism in a knockout mutant.

HEPN-AbiV is an RNase in the antiphage system AbiV

This study identifies AbiV as an RNase in the bacterial antiphage system AbiV, revealing its structure, function, and mechanism of action.

Deciphering the Transcription Factor Landscape in Neuroendocrine Prostate Cancer Progression: A Novel Approach to Understand NE Transdifferentiation

This study identifies lineage-specific transcription factor profiles in prostate cancer progression, revealing dynamic shifts during NE transdifferentiation and proposing a three-phase model.

Copper trafficking in Trypanosoma cruzi: the transcriptional response of candidates to balance toxicity and recruitment

This study investigates copper metabolism in Trypanosoma cruzi, identifying key genes and proposing a model for copper transport and distribution during different life stages.

Macrophage microRNA-146a is a central regulator of the foreign body response to biomaterial implants

This study identifies miR-146a as a key regulator of the foreign body response to biomaterial implants, showing its role in macrophage function, fibrosis, and FBGC formation.

Chalkophomycin Biosynthesis Revealing Unique Enzyme Architecture for a Hybrid Nonribosomal Peptide Synthetase and Polyketide Synthase

The paper identifies and characterizes the chm biosynthetic gene cluster responsible for chalkophomycin production in Streptomyces sp. CB00271 and proposes a biosynthesis model based on sequence analysis and structural modeling.

The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness

This study shows that Rag-GTPases regulate B cell metabolism and immunity by restraining TFEB/TFE3 to maintain mitochondrial fitness and support T-independent humoral immunity.

The discovery of antimicrobial peptides from the gut microbiome of cockroach Blattella germanica using deep learning pipeline

The paper develops a deep learning pipeline to identify antimicrobial peptides from the gut microbiome of Blattella germanica, finding two AMPs with low toxicity and antimicrobial activity.

PP2A catalytic subunit alpha is critically required for CD8+ T cell homeostasis and anti-bacterial responses

This study shows that PP2A catalytic subunit alpha is essential for CD8+ T cell homeostasis and anti-bacterial responses, with Bcl2 rescue limited to spleen.

Cross-species genomic survey reveals a single origin of the soft-shelled turtles

This study reveals that soft-shelled turtles have a single origin of their ZW-type sex chromosomes, coinciding with the Paleocene-Eocene thermal maximum.

Blocker-SELEX: A Structure-guided Strategy for Developing Inhibitory Aptamers Disrupting Undruggable Transcription Factor Interactions

This paper introduces Blocker-SELEX, a structure-guided method to design inhibitory aptamers that disrupt transcription factor interactions, demonstrating efficacy against SCAF4/SCAF8-RNAP2 and WDR5-MYC complexes.

The ICF2 gene Zbtb24 specifically regulates the differentiation of B1 cells via promoting heme synthesis

This study shows that Zbtb24 regulates B1 cell differentiation via heme synthesis, leading to impaired antibody production in T-cell independent responses.

A Day in the Life of Arabidopsis: 24-Hour Time-lapse Single-nucleus Transcriptomics Reveal Cell-type specific Circadian Rhythms

This study uses snRNA-seq to analyze circadian rhythms in Arabidopsis over 24 hours, revealing cell-type specific gene expression patterns and identifying key circadian regulators.

Inhibition of KLK8 promotes pulmonary endothelial repair by restoring VE-cadherin/Akt/FOXM1 pathway

This study shows that inhibiting KLK8 restores the VE-cadherin/Akt/FOXM1 pathway, promoting endothelial repair and reducing sepsis-induced lung injury and mortality.

Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4

This study reports the structures and mechanistic insights of PLD3 and PLD4, revealing their exonuclease activity, phosphatase function, and disease relevance.

Captivity affects mitochondrial aerobic respiration and carotenoid metabolism in the house finch (Haemorhous mexicanus)

This study shows that captivity in cages reduces red carotenoid circulation and increases mitochondrial respiratory rates in house finches, supporting a link between carotenoid metabolism and mitochondrial function.

Distinct Roles of Kif6 and Kif9 in Mammalian Ciliary Trafficking and Motility

This study identifies distinct roles of Kif6 and Kif9 in mammalian ciliary trafficking and motility, showing Kif6 is a motile cilia-specific IFT motor while Kif9 regulates the central apparatus.

Pulmonary Ventilation Analysis Using 1H Ultra-Short Echo Time (UTE) Lung MRI: A Reproducibility Study

This study evaluates methods for quantifying pulmonary ventilation using 1H UTE MRI, finding that cyclic b-spline registration and specific ventilation provide the most reproducible results.

NeuroMotion: Open-source Simulator with Neuromechanical and Deep Network Models to Generate Surface EMG signals during Voluntary Movement

NeuroMotion generates synthetic EMG signals during voluntary movements by integrating musculoskeletal models, neural networks, and motor unit models, enabling analysis of neuromechanical interactions.

Inhibition of SARS-CoV-2 Infection in Human Airway Epithelium with a Xeno-Nucleic Acid Aptamer

This study shows that FANA-R8-9 aptamer inhibits SARS-CoV-2 infection in human airway epithelium models and is stable and non-toxic.

Enhancing plant photosynthesis through activating cells deficient in photosynthetic apparatus

This study enhances plant photosynthesis by activating CGA1 in vascular bundle and bundle sheath cells, leading to increased chloroplasts, RuBisCO, and biomass with a 20% increase.

Dairy practices select for thermostable endolysins in phages

The paper shows that dairy practices have selected for thermostable endolysins in phages infecting Streptococcus thermophilus, reducing endolysin diversity.

Progressive community, biogeochemical and evolutionary remodeling of the soil microbiome underpins long-term desert ecosystem restoration

This study examines the long-term microbial changes in desert soil during ecological restoration, finding shifts in community structure, functional diversity, and biogeochemical cycles over 17 years.

The crystal and cryo-EM structures of PLCγ2 reveal dynamic inter-domain recognitions in autoinhibition

The paper determines crystal and cryo-EM structures of PLCγ2 in autoinhibited states and bound to FGFR1 kinase domain, revealing dynamic inter-domain interactions in autoinhibition.

Multiscale effects of perturbed translation dynamics inform antimalarial design

The paper determines in situ structures of Pf80S ribosomes in Plasmodium falciparum-infected erythrocytes, identifies a bifurcation in translation elongation, and links perturbations to inhibitor effects on ribosome interactions.

Massively Concurrent Sub-Cellular Traction Force Videography enabled by Single-Pixel Optical Tracers (SPOTs)

The paper introduces a high-speed, large-field-of-view platform for measuring sub-cellular traction forces in over 10,000 cells at 83 frames per second.

Host-microbiota interactions contributing to the heterogeneous tumor microenvironment in colorectal cancer

The paper identifies host-microbiota interactions in colorectal cancer subtypes, revealing distinct gene-microbe associations that contribute to tumor microenvironment heterogeneity.

A microfluidic strategy to capture antigen-specific high affinity B cells

This paper introduces a microfluidic method to assess B cell affinity to antigens under force, showing it can enrich high-affinity B cells and correlate with solution-based antibody affinity.

A framework for Frizzled-G protein coupling and implications to the Wnt-PCP signaling pathways

This study presents cryo-EM structures of FZD6, FZD3, and FZD1 in active and inactive states, revealing a shared activation framework and potential crosstalk between G-protein binding and Wnt-PCP signaling.