Author

B. K. Gilsbach

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Biochemistry· 1

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Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

A. Kortholt· 1 shared B. Riebenbauer· 1 shared C. J. Gloeckner· 1 shared F. Y. Ho· 1 shared G. Guaitoli· 1 shared X. Zhang· 1 shared

Activity by Year

2023-2023 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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1 shared paperBiochemistry

A. Kortholt

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1 paper

Recent·Most cited

Intramolecular feedback regulation of the LRRK2 Roc G domain by a LRRK2 kinase dependent mechanism

B. K. Gilsbach, F. Y. Ho, B. Riebenbauer, X. Zhang, G. Guaitoli, A. Kortholt, C. J. Gloeckner

This study identifies a kinase-dependent negative feedback mechanism regulating LRRK2 Roc G domain activity through autophosphorylation of T1343, affecting GTP hydrolysis kinetics.

bioRxiv · Jul 31, 2023 · PreprintBiochemistry