Intramolecular feedback regulation of the LRRK2 Roc G domain by a LRRK2 kinase dependent mechanism
B. K. Gilsbach, F. Y. Ho, B. Riebenbauer, X. Zhang, G. Guaitoli, A. Kortholt, C. J. Gloeckner
This study identifies a kinase-dependent negative feedback mechanism regulating LRRK2 Roc G domain activity through autophosphorylation of T1343, affecting GTP hydrolysis kinetics.
bioRxiv · Jul 31, 2023 · PreprintBiochemistry