Author

F. Y. Ho

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Kortholt· 2 shared C. J. Gloeckner· 2 shared G. Guaitoli· 2 shared X. Zhang· 2 shared B. K. Gilsbach· 1 shared B. Riebenbauer· 1 shared D. Fessas· 1 shared F. Raimondi· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

A. Kortholt

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2 papers

Recent·Most cited

Biophysical analysis reveals autophosphorylation as an important negative regulator of LRRK2 dimerization

G. Guaitoli, X. Zhang, F. Saitta, P. Miglionico, L. M. Silbermann, F. Y. Ho, F. von Zweydorf, M. Signorelli, K. Tych, D. Fessas, F. Raimondi, A. Kortholt, C. J. Gloeckner

This study uses biophysical methods to show that autophosphorylation inhibits LRRK2 dimerization, suggesting it as a negative regulator with implications for Parkinson's disease.

bioRxiv · Aug 11, 2023 · PreprintBiochemistry

Intramolecular feedback regulation of the LRRK2 Roc G domain by a LRRK2 kinase dependent mechanism

B. K. Gilsbach, F. Y. Ho, B. Riebenbauer, X. Zhang, G. Guaitoli, A. Kortholt, C. J. Gloeckner

This study identifies a kinase-dependent negative feedback mechanism regulating LRRK2 Roc G domain activity through autophosphorylation of T1343, affecting GTP hydrolysis kinetics.

bioRxiv · Jul 31, 2023 · PreprintBiochemistry