Host PGD2 acting on DP2 receptor attenuates Schistosoma mansoni infection-driven hepatic granulomatous fibrosis
G. N. Pezzella-Ferreira, C. R. R. Pao, I. Bellas, T. Luna-Gomes, V. S. Muniz, L. A. Paiva, N. R. T. Amorim, C. Canetti, P. T. Bozza, B. L. Diaz, C. Bandeira-Melo
This study investigates the role of PGD2 and its receptor DP2 in hepatic fibrosis caused by Schistosoma mansoni infection, finding that PGD2/DP2 signaling protects against fibrosis rather than promoting it.
bioRxiv · Nov 9, 2023Immunology