B. Lenz

Eosinophils are an endogenous source of IL-4 during filarial infections and contribute to the development of an optimal T helper 2 response

This study identifies eosinophils as a major source of IL-4 during filarial infections, showing their critical role in driving Th2 responses without affecting macrophage polarization or antibody production.

Nucleic acid receptor ligands improve vaccination efficacy against the filarial nematode Litomosoides sigmodontis

This study shows that adding nucleic acid receptor agonists to a vaccine against the filarial nematode Litomosoides sigmodontis improves immune response and reduces worm burden by 73%.