G. Hartmann

PLA2G15 is a Lysosomal BMP Hydrolase and Its Targeting Ameliorates Lysosomal Disease

This study identifies PLA2G15 as a lysosomal BMP hydrolase and shows its targeting improves lysosomal disease symptoms in NPC1 models.

hnRNPM and ELAVL1 control type I interferon induction by promoting IRF3 phosphorylation downstream of both cGAS and RIG-I

RIG-I activation primes and trains innate antiviral immune memory

RIG-I activation primes and trains innate immune responses, enhancing non-specific antiviral protection in immune and non-immune cells.

A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA

This study identifies an isoleucine residue in RIG-I that prevents recognition of 5p-RNA, thereby maintaining immune tolerance to mitochondrial RNA.

SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA

This study shows SAMHD1 regulates innate immunity by controlling RNA condensation, preventing immune recognition of self RNA and reducing inflammation.

Nucleic acid receptor ligands improve vaccination efficacy against the filarial nematode Litomosoides sigmodontis

This study shows that adding nucleic acid receptor agonists to a vaccine against the filarial nematode Litomosoides sigmodontis improves immune response and reduces worm burden by 73%.

Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing

This study identifies cGAS/STING/IFN-mediated nucleic acid sensing by monocyte-derived macrophages as a driver of severe pulmonary vasculitis and shows that targeting this pathway reduces disease severity.

RIG-I immunotherapy overcomes radioresistance in p53-positive malignant melanoma

This study shows that RIG-I ligands enhance radiation-induced tumor cell death and immunogenicity in melanoma, with p53 playing a key role in the synergy between RIG-I and radiation.

RIG-I-induced innate antiviral immunity protects mice from lethal SARS-CoV-2 infection

This study shows that activating the RIG-I receptor with synthetic RNA oligonucleotides before SARS-CoV-2 infection improves mouse survival and reduces viral load.

Human IFITM3 restricts Chikungunya virus and Mayaro virus infection and is susceptible to virus-mediated counteraction

This study shows IFITM3 restricts CHIKV and MAYV infection and is counteracted by these viruses, with a variant showing similar antiviral activity to wild-type.

ADA2 is a lysosomal DNase regulating the type-I interferon response

The paper identifies ADA2 as a lysosomal DNase that regulates the type-I interferon response by degrading cGAS/Sting-activating ligands in DADA2 patients.