B. Luan

Spike Protein-independent Attenuation of SARS-CoV-2 Omicron Variant in Laboratory Mice

This study shows that the Omicron variant of SARS-CoV-2 causes milder disease and lower viral load in mice, likely due to mutations outside the spike protein that block post-entry processes.

Stable Cell Clones Harboring Self-Replicating SARS-CoV-2 RNAs for Drug Screen

This paper develops a stable cell clone system harboring self-replicating SARS-CoV-2 RNAs for drug screening, identifying three novel antiviral compounds.

in silico Assessment of Antibody Drug Resistance to Bamlanivimab of SARS-CoV-2 Variant B.1.617

This paper assesses how mutations E484Q and L452R in SARS-CoV-2 variant B.1.617 affect binding to the antibody Bamlanivimab using molecular dynamics and deep learning.

Insights on SARS-CoV-2's Mutations for Evading Human Antibodies: Sacrifice and Survival

This paper investigates how the K417N mutation in SARS-CoV-2's spike protein reduces binding to neutralizing antibody CB6, enabling immune evasion despite reduced ACE2 binding affinity.

Exploring the Binding Mechanism between Human Profilin (PFN1) and Polyproline-10 through Binding Mode Screening

This study evaluates methods for predicting protein-protein interactions using PFN1 and P10 binding as a model, finding that SMD simulations correlate better with PMF results than conventional MD metrics.