SARS-CoV-2 mutations affect proteasome processing to alter CD8+ T cell responses
D. Wellington, Z. Yin, Z. Yu, R. Heilig, S. Davis, R. Fischer, S. L. Felce, P. Hublitz, R. Beveridge, D. Dong, G. Liu, X. Yao, Y. Peng, B. M. M. Kessler, T. Dong
The paper investigates how mutations in flanking regions of SARS-CoV-2 nucleoprotein epitopes affect proteasome processing and CD8+ T cell responses, finding some mutations reduce responses while others enhance them.
bioRxiv · Apr 8, 2022 · PreprintImmunology