Z. Yin

Structural basis of a regulatory switch in mammalian complex I

This study defines the structural basis of a regulatory switch in mammalian complex I by combining cryoEM structures with biochemical analysis, showing how conformational changes mediate deactivation during ischaemia.

Human Amniotic Epithelial Cells Promote Chx10-/Pax6+ Muller Glia Subpopulation Reprogramming into Photoreceptor-like Cells

This study identifies a specific Muller glia subpopulation that can be reprogrammed into photoreceptor-like cells through transplantation of human amniotic epithelial cells.

The transcription factor Zeb2 drives differentiation of age-associated B cells

The paper identifies Zeb2 as a critical transcription factor driving age-associated B-cell differentiation and autoimmunity in humans and mice.

Inhibiting YAP1 reduced abdominal aortic aneurysm formation by suppressing adventitial fibroblast phenotype transformation and migration

This study shows that inhibiting YAP1 reduces abdominal aortic aneurysm formation by preventing adventitial fibroblast transformation into myofibroblasts and migration.

RLKdb: A comprehensive curated receptor-like kinase family database

The paper introduces RLKdb, a curated database of plant receptor-like kinases, using topology-based methods to classify RLKomes and provide tools for analysis.

A bioactive peptide from the pearl has dual roles in resisting SARS-CoV-2 infection and its complications

This study identifies a bioactive peptide from a pearl oyster that inhibits SARS-CoV-2 infection and enhances ACE2 activity to treat related complications.

Efficacy of the first bioactive peptide from the pearl

The paper identifies a novel ACE-inhibitory peptide from pearl matrix and demonstrates its potential as an antihypertensive agent.

Bio-inspired mineralization collagen induce fibrocartilage regeneration after tendon-bone injury by activating Gli1+Dkk3+ progenitor cells

This study develops a bio-inspired hydrogel that promotes tendon-bone interface regeneration by activating Gli1+Dkk3+ progenitor cells, achieving 68% mechanical recovery.

Nifuroxazide Suppresses PD-L1 Expression and Enhances the Efficacy of Radiotherapy in Hepatocellular Carcinoma

This study shows nifuroxazide enhances radiotherapy in HCC by reducing PD-L1 expression and improving tumor response.

Losartan rewires ovarian cancer tumor-immune microenvironment and suppresses IGF-1 to amplify chemo-immunotherapy sensitivity

This study shows losartan improves chemo-immunotherapy effectiveness in ovarian cancer by altering the tumor microenvironment and reducing IGF-1 signaling in cancer cells.

Plant immunity activated and suppressed by a conserved effector protein family in mirid bug Riptortus pedestris

RPH1, a conserved HAMP in herbivorous insects, activates plant PTI responses, but R. pedestris evolved four paralogs to suppress this immunity.

CD4+ T cell senescence is associated with reduced reactogenicity in severe/critical COVID-19

The paper finds that higher levels of CD4+ T cell senescence in severe/critical COVID-19 patients correlate with reduced antibody responses and worse survival, especially in breakthrough infections.

Structural insights into complex I deficiency and assembly from the disease-related ndufs4-/- mouse

This study investigates the structural and functional consequences of NDUFS4 deficiency in a mouse model, revealing impaired complex I assembly and highlighting the role of NDUFAF2 in module recruitment.

A Gpr35 tuned gut-brain metabolic axis regulates depressive-like behavior

This study identifies Gpr35 as a regulator of a gut-brain metabolic axis that influences depressive-like behavior in mice, highlighting microbial metabolites as potential therapeutic targets.

A prognostic matrix code defines functional glioblastoma phenotypes and niches.

This paper identifies a matrix code based on extracellular core matrix proteins that categorizes glioblastoma tumors into prognostic groups and predicts responses to PD1 blockade.

A pair of NLRs coordinately modulates NRC3-mediated ETI responses to facilitate age-dependent immunity

The paper identifies paired NLRs in Solanaceae species and shows their coordinated role in modulating NRC3-mediated ETI to enhance age-dependent immunity.

A frameshift in Yersinia pestis rcsD leads to expression of a small HPt variant that alters canonical Rcs signalling to preserve flea-mammal plague transmission cycles

The paper shows a frameshift mutation in rcsD of Yersinia pestis produces a small Hpt variant that modifies Rcs signaling to support flea-mammal plague transmission.

Brevicidine, a bacterial non-ribosomally produced cyclic antimicrobial lipopeptide with a unique modus operandi

This study investigates brevicidine's antimicrobial mechanism against AMR Gram-negative pathogens and shows its efficacy in a mouse model.

More than 90% of nacre matrix proteins are composed of silk-like proteins

The paper identifies silk-like proteins as the main components of nacre matrix proteins, showing over 90% composition in both soluble and insoluble fractions.

IRIS: Integrated Retinal Functionality in Image Sensors

The paper introduces IRIS, a neuromorphic image sensor technology that implements retinal-inspired motion computations for improved machine vision in dynamic environments.

Structural Basis of Mammalian Respiratory Complex I Inhibition by Medicinal Biguanides

This study identifies how biguanides inhibit respiratory complex I by binding in the quinone channel and causing a chaotropic effect.

SARS-CoV-2 mutations affect proteasome processing to alter CD8+ T cell responses

The paper investigates how mutations in flanking regions of SARS-CoV-2 nucleoprotein epitopes affect proteasome processing and CD8+ T cell responses, finding some mutations reduce responses while others enhance them.

SARS-CoV-2 variant B.1.1.7 caused HLA-A2+ CD8+ T cell epitope mutations for impaired cellular immune response

This study identifies mutations in SARS-CoV-2 variant B.1.1.7 that reduce HLA-A2 restricted CD8+ T cell epitope binding and impair cellular immune responses.

Phylogenetic and protein prediction analysis reveals the taxonomically diverse distribution of virulence factors in the Bacillus cereus group

The paper analyzes the distribution of virulence factors in Bacillus cereus strains using phylogenetic and protein prediction methods, revealing clustering based on virulence genes and structural features.

Cell type specific IL-27p28 (IL-30) deletion uncovers an unexpected regulatory function of IL-30 in autoimmune inflammation

This study shows that IL-30, a subunit of IL-27, has a regulatory role in autoimmune inflammation, with its expression by APCs limiting inflammation, while dendritic cell-derived IL-30 is not required for disease development.

A novel Phytophthora sojae effector PsFYVE1 modulates transcription and alternative splicing of immunity related genes by targeting host RZ-1A protein

This paper identifies PsFYVE1, a novel effector from Phytophthora sojae, which modulates plant immunity by altering transcription and alternative splicing of immunity-related genes through interaction with host RNA-binding proteins.

Compositional phylogenomic modelling resolves the 'Zoraptera problem': Zoraptera are sister to all other polyneopteran insects

This study resolves the Zoraptera placement in insect phylogeny, finding Zoraptera as the earliest-diverging polyneopteran order and providing a Devonian origin for winged insects.

IFITM3 regulates virus-induced inflammatory cytokine production by titrating Nogo-B orchestration of TLR responses

This study shows IFITM3 limits viral pathogenesis by regulating Nogo-B-mediated TLR responses and cytokine production in dendritic cells.

Three bacterium-plasmid golden combinations facilitate the spread of ST11/CG258 carbapenemase-producing Klebsiella pneumoniae in China

The paper identifies three plasmid combinations that enhance the spread of ST11/CG258 carbapenemase-producing Klebsiella pneumoniae in China through genomic and epidemiological analysis.

The impact of viral mutations on recognition by SARS-CoV-2 specific T-cells

The paper identifies SARS-CoV-2 T-cell epitope variants that reduce recognition by T-cells, highlighting the risk of immune evasion.