Type I interferon-dependent CCL4 is induced by a cGAS/STING pathway that bypasses viral inhibition and protects infected tissue, independent of viral burden
N. J. Parekh, T. E. Krouse, I. E. Reider, R. P. Hobbs, B. M. Ward, C. C. Norbury
The paper shows that T1-IFN produced by a subset of VACV-infected cells via the cGAS/STING pathway protects mice by recruiting inflammatory monocytes, independent of viral replication.
bioRxiv · May 2, 2019Immunology