APOBEC mutagenesis inhibits breast cancer growth through induction of a T cell-mediated antitumor immune response
A. V. DiMarco, X. Qin, S. Van Alsten, B. McKinney, N. M. G. Garcia, J. Force, B. A. Hanks, M. A. Troester, K. Owzar, J. Xie, J. V. Alvarez
This study shows that APOBEC mutagenesis in breast cancer promotes T cell-mediated antitumor immunity, leading to tumor growth inhibition and sensitivity to checkpoint inhibitors.
bioRxiv · Feb 13, 2021Cancer Biology