J. Xie

Daily glycome and transcriptome profiling reveals polysaccharide structures and glycosyltransferases critical for cotton fiber growth

This study profiles the glycome and transcriptome of cotton fibers daily to identify polysaccharide structures and glycosyltransferases critical for fiber growth and quality.

Modulation of endogenous opioid signaling by inhibitors of puromycin sensitive aminopeptidase

This paper develops PSA inhibitors to prolong enkephalin stability and reduce pain, showing analgesic effects in vivo and confirming their mechanism through pharmacokinetics and modeling.

Development of alcoholic liver disease model for drug evaluation from human induced pluripotent stem cell derived liver organoids

This study develops a human induced pluripotent stem cell-derived liver organoid model of alcoholic liver disease to evaluate drug treatments and replicate key pathological features.

Exo70 promotes herpesvirus secretory vesicle tethering and virion release in an exocyst complex-dependent manner

This study identifies Exo70's role in herpesvirus secretory vesicle tethering and virion release via the exocyst complex, showing ES2 inhibits herpesvirus infection.

Epigenetic Control of Adaptive or Homeostatic Splicing of Alternative Exons and Prolactin Gene Expression During Interval-Training Activities of Pituitary Cells

This study shows that interval-training depolarization of pituitary cells triggers adaptive or homeostatic splicing of alternative exons, regulated by DNA methylation and MeCP2, while maintaining steady Prolactin gene expression.

5-Aza-Cytidine Enhances Terminal Polyadenylation Site Usage for Full-Length Transcripts in Cells

This study shows 5-aza-cytidine promotes terminal polyadenylation site usage, increasing full-length transcripts in cancer cells by altering poly(A) site selection and related factors.

Human Amniotic Epithelial Cells Promote Chx10-/Pax6+ Muller Glia Subpopulation Reprogramming into Photoreceptor-like Cells

This study identifies a specific Muller glia subpopulation that can be reprogrammed into photoreceptor-like cells through transplantation of human amniotic epithelial cells.

A General-Purpose Non-invasive Neurotechnology Research Platform

The paper introduces a non-invasive neurotechnology platform with multi-modal sensors and integration into BCI2000, demonstrating its use in sleep monitoring and evoked potentials.

Structure-Aware Dual-Target Drug Design through Collaborative Learning of Pharmacophore Combination and Molecular Simulation

AIxFuse generates dual-target drugs by learning pharmacophore fusion patterns that satisfy structural constraints from molecular docking, outperforming existing methods in success rate and binding free energy.

Short-chain carboxylates facilitate the counting of yeasts in Sub-high temperature Daqu.

This study investigates the use of short-chain carboxylates to selectively inhibit mold growth in Sub-high temperature Daqu, improving yeast counting efficiency.

Deletion of Glyoxalase 1 exacerbates acetaminophen-induced hepatotoxicity in mice

This study shows that deleting Glyoxalase 1 worsens acetaminophen-induced liver damage in mice by increasing oxidative stress and necrosis.

Impact of Cell Shape on Mitotic Spindle Positioning Forces

The paper measures how cell shape affects mitotic spindle positioning forces in sea urchin embryos, finding that viscoelastic forces increase with cell elongation.

CLAIR: An integrated lipid database across multiple crop species

The paper constructs a comprehensive lipid metabolism gene database for nine oilseed crops by integrating multi-omics data and identifying 221 additional genes.

The Aspergillus fumigatus maiA gene contributes to cell wall homeostasis and fungal virulence.

This study identifies the maiA gene in Aspergillus fumigatus as critical for cell wall homeostasis and virulence through in vitro and in vivo experiments.

The fatty liver disease-causing protein PNPLA3-I148M alters lipid droplet-Golgi dynamics

This study investigates the cellular effects of the PNPLA3-I148M variant, revealing its role in altering lipid droplet-Golgi dynamics and inducing proteomic and transcriptomic changes associated with liver disease.

Role of C2-domain protein CAR1 in the plasma membrane ABA signaling response

This study investigates CAR1's role in PM-associated ABA signaling, showing ABA affects CAR1 dynamics and its ability to recruit HAB1 and SnRK2.2 to the PM.

The sterol C-24 methyltransferase encoding gene, erg6, is essential for viability of Aspergillus species.

This paper identifies Erg6 as an essential gene for viability in Aspergillus species and shows its importance in fungal infection models.

Comprehensive multi-platform tyrosine kinase profiling reveals novel actionable FGFR aberrations across pediatric and AYA sarcomas

The paper identifies FGFR aberrations as actionable targets in pediatric and AYA sarcomas using multi-platform profiling and shows FGFR inhibitors can inhibit tumor growth in PDX models.

Mechanically stimulated osteocytes maintain tumor dormancy in bone metastasis of non-small cell lung cancer by releasing small extracellular vesicles

This study shows that mechanically stimulated osteocytes release extracellular vesicles containing microRNAs that inhibit NSCLC cell proliferation and bone metastasis progression.

Genetic excision of the regulatory cardiac troponin I extension in high heart rate mammal clades

The paper shows that genetic excision of a cardiac troponin I extension in mammals allows for high heart rates by mimicking phosphorylation without adrenergic stimulation.

Multimodal engineering of extracellular vesicles for efficient intracellular protein delivery

This paper develops VEDIC and VFIC systems for efficient intracellular protein delivery using engineered extracellular vesicles, achieving high recombination and genome editing efficiency in vitro and in vivo.

WNK1 enforces macrophage lineage fidelity

This paper identifies WNK1 as essential for macrophage lineage fidelity, showing its role in preventing myeloid progenitors from differentiating into neutrophils.

Redefinition of archetypal phytoplankton-associated bacteria taxa based on globally distributed dinoflagellates and diatoms

The paper redefines phytoplankton-associated bacterial taxa at the genus level using data from diatoms and dinoflagellates, identifying core genera and their ecological roles in the phycosphere.

STING-dependent cytosolic DNA sensing pathway drives the progression to leukemia in TET2-mutated HSPCs

This study shows that TET2 mutations cause DNA damage, activating the cGAS-STING pathway, which drives clonal hematopoiesis and leukemia, and that STING inhibition can suppress these effects in mouse and patient models.

The protist ubiquitin ligase effector PbE3-2 targets RD21A to impede plant immunity

This study identifies PbE3-2, a protist effector that degrades RD21A to suppress plant immunity, contributing to clubroot disease.

DRAM1 promotes antibacterial autophagy and lysosomal delivery of Mycobacterium marinum in macrophages

This study shows DRAM1 facilitates antibacterial autophagy and lysosomal delivery of Mycobacterium marinum in macrophages by promoting vesicle acidification and fusion.

Single-cell Landscape Analysis Unravels Molecular Programming of the Human B Cell Compartment in Chronic GVHD

This study uses scRNA-Seq to analyze B cells from allo-HCT patients, revealing molecular differences in B cell subsets associated with active versus non-active cGVHD.

Potential limitations of micro-dystrophin gene therapy for Duchenne muscular dystrophy

This study evaluates micro-dystrophin gene therapy in a DMD mouse model, finding cardiac disease acceleration with one micro-dystrophin and potential benefits with another, highlighting the need for careful dosing.

Positive effects of tree diversity on tropical forest restoration in a field-scale experiment

This study shows that planting diverse tree mixtures in logged forests accelerates restoration rates in a large field experiment.

Coevolution-based prediction of key allosteric residues for protein function regulation

This paper introduces KeyAlloSite, a method to predict key allosteric residues using coevolutionary coupling, showing its accuracy in known proteins and applications in drug design and enzyme engineering.