Increased p53 signaling impairs neural differentiation causing HUWE1-promoted intellectual disabilities
R. Aprigliano, S. Bradamante, B. Mihaljevic, W. Wang, S. L. Fordyce Martin, D. L. Bordin, M. Bosshard, N. P. Montaldo, Y. Peng, E. Alexov, C. Skinner, M. Bjoras, C. E. Schwartz, B. Van Loon
This study identifies increased p53 signaling as the cause of impaired neural differentiation in HUWE1-promoted XLIDs, showing that reducing p53 levels rescues neurodevelopmental defects.
bioRxiv · May 10, 2020Cell Biology