Enhancement of clinical signs in C3H/HeJ mice vaccinated with a highly immunogenic Leptospira methyl-accepting chemotaxis protein following challenge
L. N. Barbosa, A. LIanes, S. Madesh, B. N. Fayne, K. Brangulis, S. C. Linn-Peirano, S. Rajeev
This study evaluates a recombinant Leptospira methyl-accepting chemotaxis protein (MCP) vaccine in C3H/HeJ mice, finding it elicits an immune response but does not prevent disease and may exacerbate clinical signs.
bioRxiv · Apr 17, 2024 · PreprintMicrobiology