A Sterol-PI(4)P exchanger controls the Tel1/ATM axis of the DNA Damage Response
S. Ovejero, S. Kumanski, C. Soulet, J. Azarli, B. Pardo, O. Santt, A. Constantinou, P. Pasero, M. Moriel-Carretero
The paper shows that lipid droplets modulate the DNA Damage Response by stabilizing PI(4)P at the Golgi, which affects ATM activity and DNA repair kinetics.
bioRxiv · Jul 13, 2022Cell Biology