Author

A. Constantinou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 5 Research Focus:cell signaling & trafficking· 4 Research Focus:chromatin & epigenetic regulation· 4 Assay:proteomics· 3 Assay:ChIP-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

J. Basbous· 4 shared C. Ribeyre· 3 shared E. Alghoul· 2 shared M. Larroque· 2 shared R. Lebdy· 2 shared S. Urbach· 2 shared A. Aze· 1 shared A. Barducci· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersCell Biology

J. Basbous

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

KIF2C-induced nuclear condensation concentrates PLK1 and phosphorylated BRCA2 at the kinetochore microtubules in mitosis

A. Skobelkina, M. Julien, S. Jeannin, S. Miron, T. Egger, R. Chaaban, G. Bouvignies, R. Ghouil, C. Friel, D. BUSSO, F.-X. Theillet, R. Le Bars, A. Carreira, A. Constantinou, J. Basbous, S. ZINN-JUSTIN

The paper shows KIF2C forms condensates during mitosis that concentrate PLK1 and phosphorylated BRCA2 at kinetochore microtubules, enhancing their kinase activity and attachment stability.

bioRxiv · Apr 13, 2024Cell Biology

Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair

E. Alghoul, M. Paloni, A. Takedachi, S. Urbach, A. Barducci, P.-H. L. Gaillard, J. Basbous, A. Constantinou

This study shows SLX4 forms membraneless compartments that regulate SUMO-RNF4 pathway activity and DNA repair processes.

bioRxiv · Sep 20, 2022Biochemistry

A Sterol-PI(4)P exchanger controls the Tel1/ATM axis of the DNA Damage Response

S. Ovejero, S. Kumanski, C. Soulet, J. Azarli, B. Pardo, O. Santt, A. Constantinou, P. Pasero, M. Moriel-Carretero

The paper shows that lipid droplets modulate the DNA Damage Response by stabilizing PI(4)P at the Golgi, which affects ATM activity and DNA repair kinetics.

bioRxiv · Jul 13, 2022Cell Biology

The organizer of chromatin topology RIF1 ensures cellular resilience to DNA replication stress.

C. Ribeyre, R. Lebdy, J. Patouillard, M. Larroque, R. Abou-Merhi, C. Larroque, A. Constantinou

This study shows RIF1 stabilizes chromatin topology to reduce DNA replication stress-induced genomic instability.

bioRxiv · Oct 22, 2021Cell Biology

TopBP1 assembles nuclear condensates to switch on ATR signalling.

C. Frattini, A. Promonet, E. Alghoul, S. Vidal Eychenie, M. Lamarque, M.-P. Blanchard, S. Urbach, J. Basbous, A. Constantinou

This study shows TopBP1 forms condensates to activate ATR signaling, which phosphorylates Chk1 and slows replication forks.

bioRxiv · Oct 5, 2020Cell Biology

KDM5 histone-demethylases contribute to replication stress response and tolerance.

M. Vandromme, S. Gaillard, V. Charasson, C. Ribeyre, K. Salifou, M.-J. Pillaire, J.-S. Hoffmann, A. Constantinou, D. Trouche

This study shows KDM5A and KDM5B contribute to replication stress response and tolerance through mechanisms independent of their demethylase activity.

bioRxiv · Dec 16, 2019 · PreprintCancer Biology

Dihydropyrimidinase protects from DNA replication stress caused by cytotoxic metabolites.

J. Basbous, A. Aze, L. Chaloin, R. Lebdy, D. Hodroj, C. Ribeyre, M. Larroque, C. Shepard, B. Kim, A. Pruvost, J. Moreaux, D. Maiorano, M. Mechali, A. Constantinou

This study shows dihydropyrimidines are cytotoxic metabolites that cause DNA replication stress and DPCs, suggesting DHP inhibition could target solid tumors.

bioRxiv · Mar 5, 2019Cancer Biology