Host F-box protein 22 enhances the uptake of Brucella by macrophages and drives a sustained release of pro-inflammatory cytokines through degradation of the anti-inflammatory effector proteins of Brucella.
G. Radhakrishnan, V. Mazumdar, K. Joshi, B. R. Nandi, S. Namani, V. K. Gupta
This study identifies FBXO22 as a host protein that enhances Brucella uptake by macrophages and promotes pro-inflammatory cytokine release by degrading Brucella anti-inflammatory effectors.
bioRxiv · Mar 15, 2021 · PreprintMicrobiology