V. K. Gupta

Characterization of B646L (p72) gene and the resistance pattern of African swine fever Virus tolerant to indigenous Doom Pig breeds of India

This study characterizes the B646L (p72) gene of ASFV genotype II in Doom pigs from North-East India and identifies immune-related genes associated with ASF resistance.

Incidences of Helicobacter infection in pigs and tracing occupational hazard in pig farmers

The paper assesses Helicobacter prevalence in pigs and pig farmers, finding 19.63% of pig stomach samples and 2.08% of farmer stool samples positive for H. suis, with 3.12% positive for H. pylori.

Mass spectrometric analysis and biostimulatory effects of boar seminal gel, saliva and semen in pigs

The paper identifies novel biostimulatory compounds in boar seminal gel, saliva, and semen using GC-MS and shows that combined exposure enhances training and estrus induction in pigs.

Hormonal Interventions for optimizing reproductive efficiency in pigs at Farmers field

The paper evaluates four hormonal protocols for improving reproductive efficiency in pigs, finding that protocols II and III are most effective and cost-efficient.

Whole-Genome Sequence of African Swine Fever Virus isolate from India provides insights into diversity and evolution

The paper reports the whole-genome sequence of an African swine fever virus isolate from India and compares it to other ASFV genomes to study genetic diversity and evolution.

Systemic infection of SARS-CoV-2 in free ranging Leopard (Panthera pardus fusca) in India

The paper reports SARS-CoV-2 infection in a free-ranging Indian leopard, confirming Delta variant infection and highlighting the need for wildlife screening.

Cationic inhalable particles for enhanced drug delivery to M. tuberculosis infected macrophages

This study shows cationic inhalable microparticles enhance drug delivery to Mtb-infected macrophages, improving anti-bacterial function and uptake in vitro and in mice lungs.

The Effect of Minnelide against SARS-CoV-2 in a Murine Model

This study evaluates Minnelide's efficacy in treating SARS-CoV-2 infection in mice, showing reduced viral load, improved survival, and decreased inflammation.

Host F-box protein 22 enhances the uptake of Brucella by macrophages and drives a sustained release of pro-inflammatory cytokines through degradation of the anti-inflammatory effector proteins of Brucella.

This study identifies FBXO22 as a host protein that enhances Brucella uptake by macrophages and promotes pro-inflammatory cytokine release by degrading Brucella anti-inflammatory effectors.

Diet induced hyperlipidemia confers resistance to standard therapy in pancreatic cancer by selecting for "tumor protective" microbial metabolites and treatment refractory cells.

This study shows that a high-fat diet in pancreatic cancer mice increases resistance to chemotherapy by promoting microbial metabolites like queuosine, which protect tumors through PRDX1 upregulation, and this resistance can be reversed by S-adenosyl methionine.

The nature of mitotic forces in epithelial monolayers

This study identifies two distinct stages of mitotic force generation in epithelial monolayers: protrusive forces driving mitotic elongation and outward forces facilitating post-mitotic re-spreading.

Stroma secreted IL6 selects for stem-like population and alters pancreatic tumor microenvironment by reprogramming metabolic pathways

This study shows that stromal IL6 promotes stem-like cells and metabolic reprogramming in pancreatic tumors, creating an immune-evasive microenvironment that can be targeted to improve checkpoint inhibitor therapy.

Hypoxia driven oncometabolite L-2HG maintains "stemness"-differentiation balance and facilitates immune suppression in pancreatic cancer

This study shows hypoxia drives L-2HG production in pancreatic tumors, maintaining stemness-differentiation balance and promoting immune suppression, with LDH inhibition reversing these effects.

Rapamycin-PLGA microspheres induce autophagy and prevent senescence in chondrocytes and exhibit long in vivo residence

This paper develops rapamycin-loaded PLGA microspheres that induce autophagy and prevent chondrocyte senescence, showing sustained drug release and prolonged joint residence in mice.

Targeting tumor intrinsic metabolic node in pancreatic cancer causes tumor regression, remodels extracellular matrix and sensitizes to anti-PD1 therapy.

This study shows that targeting the HBP metabolic node in pancreatic cancer with DON reduces tumor growth, remodels the ECM, and enhances response to anti-PD1 therapy.

Long non-coding RNA GAS5 acts as proliferation brakes in CD133+ cells responsible for tumor recurrence

This study shows GAS5 regulates quiescence and growth arrest in CD133+ cells, which drive tumor recurrence in pancreatic cancer by inhibiting cell cycle progression and altering metabolic pathways.

O-GlcNAc modification of oncogenic transcription factor Sox2 promotes protein stability and regulates self-renewal in pancreatic cancer

This study shows that O-GlcNAc modification of Sox2 stabilizes the protein and enhances self-renewal in pancreatic cancer, with targeting OGT reducing tumor burden.