Redistribution of cholesterol from vesicle to plasmalemma controls fusion pore geometry
B. Rituper, A. Gucek, M. Lisjak, U. Gorska, A. Sakanovic, S. Trkov Bobnar, E. Lasic, M. Bozic, P. S. Abbineni, J. Jorgacevski, M. Kreft, A. Verkhratsky, F. M. Platt, G. Anderluh, M. Stenovec, , R. Zorec
The paper shows that cholesterol redistribution from vesicles to the plasmalemma constricts the fusion pore, while depletion widens it, proposing a cholesterol-dependent mechanism for pore geometry regulation.
bioRxiv · Apr 6, 2020 · PreprintCell Biology