A. Gucek

Local PI(4,5)P2 generation controls fusion pore expansion during exocytosis

The paper shows that local PI(4,5)P2 signaling controls fusion pore expansion during exocytosis by recruiting endocytic machinery and preventing peptide release.

Redistribution of cholesterol from vesicle to plasmalemma controls fusion pore geometry

The paper shows that cholesterol redistribution from vesicles to the plasmalemma constricts the fusion pore, while depletion widens it, proposing a cholesterol-dependent mechanism for pore geometry regulation.

Fusion pore regulation by Epac2/cAMP controls cargo release during insulin exocytosis

This study shows that Epac2/cAMP regulates fusion pore expansion in insulin exocytosis, affecting hormone and transmitter release balance.