The Origin Recognition Complex requires chromatin tethering by a hypervariable intrinsically disordered region that is functionally conserved from sponge to man
O. A. Adiji, B. S. McConnell, M. W. Parker
This paper shows that the ORC's chromatin tethering is mediated by an IDR in Orc1, which is functionally conserved across metazoans despite structural divergence.
bioRxiv · May 11, 2023Biochemistry