Author

M. W. Parker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 7 Biophysics· 3 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 10 Research Focus:chromatin & epigenetic regulation· 6 Organism:human· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:cell signaling & trafficking· 3 Organism:Drosophila· 3 Research Focus:protein folding & dynamics· 3 Approach:biophysical modeling· 2

Frequent Co-Authors

C. J. Morton· 2 shared C. M. Weekley· 2 shared E. Hanssen· 2 shared J. A. Kao· 2 shared J. M. Berger· 2 shared M. R. Botchan· 2 shared T. Boecking· 2 shared A. Behren· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

C. J. Morton

Mutual co-authors in cluster

Author profile →

12 papers

Recent·Most cited

Vgamma9Vdelta2 T cells recognize butyrophilin 2A1 and 3A1 heteromers

T. S. Fulford, C. Soliman, R. G. Castle, M. Rigau, Z. Ruan, O. Dolezal, R. Seneviratna, H. G. Brown, E. Hanssen, A. Hammet, S. Li, S. J. Redmond, A. Chung, M. A. Gorman, M. W. Parker, , A. P. Uldrich

The paper reveals that Vgamma9Vdelta2 T cells recognize BTN2A1 and BTN3A1 heteromers through dual epitope engagement, uncovering a new mechanism of immune activation.

bioRxiv · Aug 30, 2023Immunology

The Origin Recognition Complex requires chromatin tethering by a hypervariable intrinsically disordered region that is functionally conserved from sponge to man

O. A. Adiji, B. S. McConnell, M. W. Parker

This paper shows that the ORC's chromatin tethering is mediated by an IDR in Orc1, which is functionally conserved across metazoans despite structural divergence.

bioRxiv · May 11, 2023Biochemistry

Covalent inhibition by a natural product-inspired latent electrophile

D. P. Byun, J. Ritchie, R. Holewinski, H.-R. Kim, R. Tagirasa, J. Ivanic, C. M. Weekley, M. W. Parker, T. Adresson, E. Yoo

This study evaluates the reactivity and selectivity of 3-bromo-4,5-dihydroxazole electrophiles against human cysteine residues and validates their covalent binding to specific targets.

bioRxiv · Jan 16, 2023Biochemistry

Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure

K. M. R. Faysal, J. C. Walsh, N. Renner, C. L. Marquez, V. Shah, A. J. Tuckwell, M. P. Christie, M. W. Parker, S. G. Turville, L. James, G. J. Towers, D. A. Jacques, T. Boecking

This study shows Lenacapavir's antiviral effect comes from hyperstabilizing the HIV-1 capsid lattice, leading to loss of compartmentalization and capsid failure.

bioRxiv · Sep 21, 2022Biophysics

Structures of the interleukin 11 signalling complex reveal dynamics of gp130 extracellular domains and the inhibitory mechanism of a cytokine variant

R. D. Metcalfe, E. Hanssen, K. Y. Fung, K. Aizel, C. C. Kosasih, C. O. Zlatic, L. Doughty, C. J. Morton, A. P. Leis, M. W. Parker, P. R. Gooley, T. L. Putoczki, M. D. W. Griffin

This study presents cryo-EM and crystal structures of the IL-11 signalling complex, revealing dynamics of gp130 and the inhibitory mechanism of a cytokine variant.

bioRxiv · Jul 21, 2022Cell Biology

DNA-Stimulated Liquid-Liquid Phase Separation by Eukaryotic Topoisomerase II Modulates Catalytic Function

J. Jeong, J. H. Lee, C. C. Carcamo, M. W. Parker, J. M. Berger

This study shows that DNA-induced phase separation of eukaryotic type IIA topoisomerases switches their function from DNA unlinking to catenation.

bioRxiv · Jul 11, 2022Biochemistry

Single-molecule analysis of the entire perfringolysin O poreformation pathway

C. Mc Guinness, J. Walsh, C. Bayly-Jones, M. Dunstone, C. Morton, M. Christie, M. W. Parker, T. Boecking

This study uses single-molecule fluorescence imaging to analyze the kinetics of PFO pore formation, revealing that membrane insertion is kinetically controlled.

bioRxiv · Oct 19, 2021Biophysics

Molecular determinants of phase separation for Drosophila DNA replication licensing factors

M. W. Parker, J. A. Kao, A. T. Huang, J. M. Berger, M. R. Botchan

This study identifies molecular mechanisms underlying phase separation in Drosophila DNA replication licensing factors, showing that DNA-bridging and hydrophobic interactions drive condensate formation and specificity.

bioRxiv · Apr 12, 2021Biophysics

SARS-CoV-2 Spike receptor-binding domain with a G485R mutation in complex with human ACE2

C. M. Weekley, D. F. J. Purcell, M. W. Parker

This study reports the crystal structure of SARS-CoV-2 Spike RBD with a G485R mutation bound to human ACE2, showing structural changes that may affect antigenic escape.

bioRxiv · Mar 16, 2021 · PreprintBiochemistry

Mutations in an intracellular vestibule that bifurcates from the pore of ClC-1 chloride ion channels affect anion permeation

B. Bennetts, C. J. Morton, M. W. Parker

This study shows that structural differences outside the conserved Cl ion pathway in ClC-1 channels affect anion permeation by altering interactions between permeating anions and selectivity.

bioRxiv · Nov 1, 2020 · PreprintBiochemistry

Monoubiquitination by the Fanconi Anemia core complex locks FANCI:FANCD2 on DNA in filamentous arrays

W. Tan, S. van Twest, A. Leis, R. Bythell-Douglas, V. J. Murphy, M. Sharp, M. W. Parker, W. M. Crismani, A. J. Deans

This study shows that monoubiquitination of FANCD2 stabilizes the FANCI:FANCD2 complex on DNA and forms filamentous arrays, revealing a mechanism for DNA repair pathway activation.

bioRxiv · Dec 3, 2019Biochemistry

A new class of disordered elements controls DNA replication through initiator self-assembly

M. W. Parker, M. Bell, M. Mir, J. A. Kao, X. Darzacq, M. R. Botchan, J. M. M. Berger

This study identifies a new class of disordered elements that drive liquid-liquid phase separation in DNA replication initiators in D. melanogaster.

bioRxiv · Apr 29, 2019Biochemistry