ImmunologybioRxiv
Enhanced differentiation of functional human T cells in NSGW41 mice with tissue-specific expression of human interleukin-7.
E. Coppin, B. S. Sundarasetty, S. Rahmig…·A. Krueger
This study creates a humanized mouse model with enhanced T cell differentiation by expressing human IL-7 in specific tissues, leading to increased functional T cells without lymphoproliferation.
DOI 10.1038/s41375-021-01259-5