A. Krueger

The biophysical basis of bacterial colony growth

This study shows that the horizontal expansion rate of bacterial colonies is controlled by the contact angle at the biofilm edge, validated through experimental measurements and theoretical modeling.

Single NV in nanodiamond for quantum sensing of protein dynamics in an ABEL trap

The paper uses a single NV center in a nanodiamond within an ABEL trap to quantum-sense protein dynamics, specifically tracking ATP-driven conformational changes in FoF1-ATP synthase with high spatio-temporal resolution.

A high-resolution map of functional miR-181 response elements in the thymus reveals the role of coding sequence targeting and an alternative seed match

This study maps miR-181 response elements in murine T-cells, revealing novel targets and an alternative seed match mechanism for miR-181 action.

High-resolution mapping of cell-cycle dynamics during T-cell development and regeneration in vivo

This study maps cell-cycle dynamics during T-cell development and regeneration using in vivo labeling and modeling, revealing phase adjustments that maintain homeostasis.

Structural and biochemical characterisation of the N-Carbamoyl-beta-Alanine Amidohydrolases from Rhizobium radiobacter MDC 8606

This study characterizes the structure and biochemical properties of N-Carbamoyl-beta-Alanine Amidohydrolase from Rhizobium radiobacter MDC 8606, revealing its substrate specificity and potential for industrial applications.

Insights from CRISPR/Cas9-mediated gene editing of centromeric histone H3 (CENH3) in carrot (Daucus carota subsp. sativus)

This paper explores CRISPR/Cas9-mediated editing of CENH3 in carrot to induce haploidy, identifies a second CENH3 locus, and evaluates mutant constructs for potential haploid inducer use.

Immobilised enzyme cascade for targeted glycosylation

The paper introduces a platform for controlled N-linked glycosylation using immobilized enzymes, achieving high conversion and reusability for industrial applications.

An early decline in ETPs reflects reduced pre-thymic progenitors and altered signals from the thymus microenvironment

The paper shows that early T-cell progenitors decline by 3 months in mice due to reduced pre-thymic progenitors and diminished Notch signaling.

HIF2α is a Direct Regulator of Neutrophil Motility

This study identifies HIF2α as a regulator of neutrophil motility through the PHD2-HIF2-RhoA axis, enhancing migration in hypoxic environments during inflammation.

Enhanced differentiation of functional human T cells in NSGW41 mice with tissue-specific expression of human interleukin-7.

This study creates a humanized mouse model with enhanced T cell differentiation by expressing human IL-7 in specific tissues, leading to increased functional T cells without lymphoproliferation.

Muscle overexpression of Klf15 via an AAV8-Spc5-12 construct does not provide benefits in spinal muscular atrophy mice

This study tests if muscle-specific Klf15 overexpression via AAV8 improves SMA mouse survival, finding limited efficacy in some models.

Germline deletion reveals a non-essential role of the atypical MAPK6/ERK3

The paper shows that ERK3 is not essential for viability, fertility, or T-cell function, contradicting previous reports of perinatal lethality due to a different genetic construct.

Hematopoietic stem cells differentiate into restricted myeloid progenitors before cell division

This study shows hematopoietic stem cells can differentiate into restricted progenitors without dividing or entering the S phase, indicating fate decisions are uncoupled from cell division.