Author

I. Prinz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 7 Research Focus:cell type annotation· 6 Approach:experimental assay· 6 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2 Assay:flow cytometry· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2

Frequent Co-Authors

S. Ravens· 3 shared A. Krueger· 2 shared I. Sandrock· 2 shared K. L. Edelblum· 2 shared N. B. Golovchenko· 2 shared R. Foerster· 2 shared U. Panzer· 2 shared A. Borchers· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersImmunology

S. Ravens

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

The integrated stress response/eIF2α pathway controls cytokine production in tissue-resident memory CD4+ T cells

N. Asada, P. Ginsberg, H.-J. Paust, N. Song, J.-H. Riedel, J.-E. Turner, A. Peters, A. Kaffke, J. Engesser, H. Wang, Y. Zhao, P. Gild, R. Dahlem, S. Das, Z. Ignatova, , U. Panzer

This study shows that the ISR/eIF2α pathway regulates cytokine mRNA translation in Trm cells, limiting their activity in homeostasis but enabling rapid response during inflammation or autoimmunity.

bioRxiv · Jan 26, 2024Immunology

Dysregulation of γδ intraepithelial lymphocytes precedes Crohn's disease-like ileitis

W. Xu, N. B. Golovchenko, A. Fong, S. Achi, E. B. Bucar, K. J. Vidmar, L. Zhang, M. R. Frey, I. Prinz, T. T. Pizarro, G. Kollias, K. L. Edelblum

This study identifies dysregulation of γδ intraepithelial lymphocytes (IELs) before the onset of Crohn's disease-like ileitis in a mouse model.

bioRxiv · Aug 31, 2023Immunology

Adult thymus-derived cMaf+ RORγt+ γδ T cells lack Scart2 chromatin accessibility and do not reach periphery

T. Yang, J. Barros-Martins, A. Janssen, Z. Wang, X. Leon-Lara, S. Weiss, I. Prinz, R. Foerster, S. Ravens

bioRxiv · Feb 20, 2023 · PreprintImmunology

γδ intraepithelial lymphocytes facilitate pathological epithelial cell shedding via CD103-mediated granzyme release.

M. D. Hu, N. B. Golovchenko, T. J. Kelly, J. Agos, M. R. Zeglinski, E. M. Bonder, I. Sandrock, I. Prinz, D. J. Granville, A. J. M. Watson, K. L. Edelblum

This study identifies γδ intraepithelial lymphocytes as facilitators of pathological epithelial cell shedding through CD103-mediated granzyme release in response to LPS.

bioRxiv · Jan 20, 2021Immunology

Influenza A virus-induced thymus atrophy differentially affects dynamics of conventional and regulatory T cell development

Y. Elfaki, P. A. Robert, C. Binz, C. S. Falk, D. Bruder, I. Prinz, S. Flöss, M. Meyer-Hermann, J. Hühn

This study investigates how influenza A virus-induced thymus atrophy affects Treg cell development and shows a relative increase in tTreg cells with reduced TCR diversity.

bioRxiv · Sep 9, 2020Immunology

A fetal wave of human type-3 γδ T cells with restricted TCR diversity persists into adulthood

L. Tan, A. S. Fichtner, A. Bubke, I. Odak, C. Schultze-Florey, C. Koenecke, R. Foerster, M. Jarek, C. v. Kaisenberg, A. Borchers, U. Panzer, C. Krebs, S. Ravens, I. Prinz

The paper identifies a fetal wave of human type-3 γδ T cells with restricted TCR diversity that persists into adulthood using single-cell RNA-sequencing and TCR-sequencing.

bioRxiv · Aug 14, 2020Immunology

Enhanced differentiation of functional human T cells in NSGW41 mice with tissue-specific expression of human interleukin-7.

E. Coppin, B. S. Sundarasetty, S. Rahmig, J. Blume, N. A. Verheyden, F. Bahlmann, S. Ravens, U. Schubert, J. Schmid, S. Ludwig, C. von Kaisenberg, A. Platz, R. Naumann, B. Ludwig, I. Prinz, , A. Krueger

This study creates a humanized mouse model with enhanced T cell differentiation by expressing human IL-7 in specific tissues, leading to increased functional T cells without lymphoproliferation.

bioRxiv · Apr 24, 2020Immunology

Germline deletion reveals a non-essential role of the atypical MAPK6/ERK3

N. Ronkina, K. Schuster-Gossler, F. Hansmann, H. Kunze-Schumacher, I. Sandrock, T. Yakovleva, J. Lafera, W. Baumgärtner, A. Krueger, I. Prinz, A. Gossler, A. Kotlyarov, M. Gaestel

The paper shows that ERK3 is not essential for viability, fertility, or T-cell function, contradicting previous reports of perinatal lethality due to a different genetic construct.

bioRxiv · Nov 10, 2018Cell Biology