A revised mechanism of action of hyperaldosteronism-linked mutations in cytosolic domains of GIRK4 (KCNJ5).
B. Shalomov, R. Handklo-Jamal, H. P. Reddy, N. Theodor, A. K. Bera, N. Dascal
This study shows that cytosolic domain mutations in GIRK4 (KCNJ5) cause loss-of-function rather than gain-of-function, challenging the existing mechanism of hyperaldosteronism.
bioRxiv · Dec 9, 2019Physiology