Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation
X. Chen, B. Sunkel, M. Wang, S. Kang, T. Wang, J. R. Gnanaprakasam, L. Liu, T. A. Cassel, D. A. Scott, A. M. Munoz-Cabello, J. Lopez-Barneo, J. Yang, A. N. Lane, G. Xin, B. Stanton, , R. Wang
This study shows that succinate dehydrogenase/complex II is essential for T cell proliferation and inflammation by regulating metabolic flux and epigenetic modifications.
bioRxiv · Oct 26, 2021Immunology