Author

T. A. Cassel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:metabolomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:metabolism & bioenergetics· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. N. Lane· 3 shared J. R. Gnanaprakasam· 3 shared L. Liu· 3 shared R. Wang· 3 shared S. Kang· 3 shared T. Wang· 3 shared X. Chen· 3 shared D. A. Scott· 2 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

A. N. Lane

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Biphasic response of CD8 T cell to asparagine restriction maximizes its metabolic fitness and antitumoral functionality

J. R. Gnanaprakasam, L. Liu, X. Chen, S. Kang, T. Wang, T. A. Cassel, C. M. Adams, R. M. Higashi, D. A. Scott, G. Xin, J. Yang, A. N. Lane, T. W. Fan, J. Zhang, R. Wang

This study shows that asparagine restriction induces a biphasic response in CD8 T cells, enhancing their metabolic fitness and antitumoral function through ATF4/NRF2-dependent mechanisms.

bioRxiv · Jul 18, 2022 · PreprintImmunology

Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation

X. Chen, B. Sunkel, M. Wang, S. Kang, T. Wang, J. R. Gnanaprakasam, L. Liu, T. A. Cassel, D. A. Scott, A. M. Munoz-Cabello, J. Lopez-Barneo, J. Yang, A. N. Lane, G. Xin, B. Stanton, , R. Wang

This study shows that succinate dehydrogenase/complex II is essential for T cell proliferation and inflammation by regulating metabolic flux and epigenetic modifications.

bioRxiv · Oct 26, 2021Immunology

Inosine is an alternative carbon supply that supports effector T cell proliferation and anti-tumor function under glucose restriction

T. Wang, J. R. Gnanaprakasam, X. Chen, S. Kang, X. Xu, H. Sun, L. Liu, E. Miller, T. A. Cassel, Q. Sun, S. Vicente-Munoz, M. O. Warmoes, A. N. Lane, X. Song, T. W.- M. Fan, R. Wang

This study shows that effector T cells use inosine as an alternative carbon source under glucose restriction, enhancing anti-tumor function and bypassing tumor-imposed metabolic limitations.

bioRxiv · Sep 14, 2019 · PreprintImmunology