A thermostable Cas9 with increased lifetime in human plasma
L. Harrington, D. Paez-Espino, J. S. Chen, E. Ma, B. T. Staahl, N. C. Kyrpides, J. A. Doudna
This paper describes a thermostable Cas9 variant from Geobacillus stearothermophilus that functions at higher temperatures and has increased stability in human plasma, expanding CRISPR-Cas9 applications.
bioRxiv · May 16, 2017Biochemistry