Inflammatory stress signaling via NF-kB alters accessible cholesterol to upregulate SREBP2 transcriptional activity in endothelial cells
W. C. Sessa, J. W. M. Fowler, R. Zhang, B. Tao, N. E. Boutagy
This study shows that inflammatory stress via NF-kB reduces accessible cholesterol, enhancing SREBP2 activity in endothelial cells, linking cholesterol homeostasis to inflammation.
bioRxiv · May 5, 2022 · PreprintCell Biology