Author

B. W. Higgins

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Organism:mouse· 4 Assay:scRNA-seq· 4 Research Focus:clustering· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

L. J. McHeyzer-Williams· 5 shared M. G. McHeyzer-Williams· 5 shared A. G. Shuparski· 4 shared K. B. Miller· 4 shared A. M. Robinson· 2 shared A. G. Suparski· 1 shared C. R. Dufaud· 1 shared P. J. Milpied· 1 shared

Activity by Year

2021-2022 · peak 4/yr

Co-Author Collaboration Network

9 top collaborators · 25 mutual co-author links

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5 shared papersImmunology

L. J. McHeyzer-Williams

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5 papers

Recent·Most cited

Follicular helper T cells expressing Blimp1 are specialized for plasma cell differentiation

K. B. Miller, A. G. Suparski, B. W. Higgins, S. M. Sharma, P. J. Milpied, L. J. McHeyzer-Williams, M. G. McHeyzer-Williams

This paper identifies Blimp1-expressing TFH cells as specialized for plasma cell differentiation, distinct from Bcl6-expressing GC-TFH cells, and shows their role in generating high-affinity immunity.

bioRxiv · Mar 31, 2022 · PreprintImmunology

PD-1 checkpoint blockade activates germinal center follicular T cell programs that disrupt type 2 isotype-specific antibody homeostasis

A. G. Shuparski, B. W. Higgins, K. B. Miller, L. J. McHeyzer-Williams, M. G. McHeyzer-Williams

Acute PD-1 blockade disrupts type 2 isotype-specific antibody homeostasis by amplifying TFH2 programs and altering GC B cell dynamics.

bioRxiv · Sep 27, 2021 · PreprintImmunology

Evolution of antigen-specific follicular helper T cell transcriptional programs across effector function and through to memory

A. M. Robinson, B. W. Higgins, A. G. Shuparski, K. B. Miller, L. J. McHeyzer-Williams, M. G. McHeyzer-Williams

This study identifies antigen-specific transcriptional programs in follicular helper T cells across effector function and memory development, revealing distinct inflammatory and anti-inflammatory modules.

bioRxiv · Sep 17, 2021 · PreprintImmunology

Programming isotype specific plasma cell differentiation

B. W. Higgins, A. G. Shuparski, K. B. Miller, A. M. Robinson, L. J. McHeyzer-Williams, M. G. McHeyzer-Williams

This study identifies isotype-specific molecular programs in murine plasma cells, revealing distinct pathways for IgM, IgG1, IgG2a/b, and IgA that govern antigen clearance and immune protection.

bioRxiv · Aug 31, 2021 · PreprintImmunology

PD-1 checkpoint blockade disrupts CD4 T cell regulated adaptive B cell tolerance to foreign antigens

C. R. Dufaud, A. G. Shuparski, B. W. Higgins, L. J. McHeyzer-Williams, M. G. McHeyzer-Williams

The paper shows PD-1 blockade disrupts CD4 T cell regulation of B cell tolerance, leading to increased IgG1 plasma cell differentiation and anti-commensal antibody production.

bioRxiv · Jun 10, 2021 · PreprintImmunology