PD-1 checkpoint blockade disrupts CD4 T cell regulated adaptive B cell tolerance to foreign antigens
C. R. Dufaud, A. G. Shuparski, B. W. Higgins, L. J. McHeyzer-Williams, M. G. McHeyzer-Williams
The paper shows PD-1 blockade disrupts CD4 T cell regulation of B cell tolerance, leading to increased IgG1 plasma cell differentiation and anti-commensal antibody production.
bioRxiv · Jun 10, 2021 · PreprintImmunology