Novel inhibitors of TTLL12s oncogenic potential that overcome suppression of ligation of nitrotyrosine to the C-terminus of detyrosinated a-tubulin
A. Deshpande, J. Brants, C. Wasylyk, O. van Hooij, G. W. Verhaegh, P. Mass, J. A. Schalken, B. Wasylyk
The paper identifies two molecules that activate nitrotyrosine ligation to detyrosinated α-tubulin by targeting TTLL12, which suppresses this process, suggesting potential therapeutic applications for cancer and related pathologies.
bioRxiv · Dec 28, 2023 · PreprintCancer Biology