A. Deshpande

Elasticity of the HIV-1 Core Facilitates Nuclear Entry and Infection

This study shows that HIV-1 core elasticity is essential for nuclear entry and infection, with capsid-targeting drugs reducing elasticity and impairing infectivity.

Tumor cell-based liquid biopsy using high-throughput microfluidic enrichment of entire leukapheresis product

This study uses high-throughput microfluidic technology to enrich CTCs from large blood volumes, enabling detailed molecular and morphological analysis of tumor cells in metastatic cancer patients.

Novel inhibitors of TTLL12s oncogenic potential that overcome suppression of ligation of nitrotyrosine to the C-terminus of detyrosinated a-tubulin

The paper identifies two molecules that activate nitrotyrosine ligation to detyrosinated α-tubulin by targeting TTLL12, which suppresses this process, suggesting potential therapeutic applications for cancer and related pathologies.

NEUROEPITHELIAL BODIES AND TERMINAL BRONCHIOLES ARE NICHES FOR DISTINCTIVE CLUB CELLS THAT CAN REPAIR AIRWAYS FOLLOWING ACUTE NOTCH INHIBITION

This study investigates how Notch inhibition affects airway club cells, showing that a subpopulation can repair airways by reverting to a progenitor state.

Informing virtual clinical trials of hepatocellular carcinoma with spatial multi-omics analysis of a human neoadjuvant immunotherapy clinical trial

The paper develops a spatial quantitative systems pharmacology model for virtual clinical trials in HCC, validated with spatial multi-omics data from a neoadjuvant immunotherapy trial.

Inoculum-dependent bactericidal activity of a Mycobacterium tuberculosis MmpL3 inhibitor

The paper examines the bactericidal activity of NITD-349, an MmpL3 inhibitor, showing inoculum-dependent kill kinetics and enhanced efficacy when combined with isoniazid.

Description of Protosticta armageddonensis sp. nov. (Odonata: Zygoptera: Platystictidae) from the Western Ghats of India

The paper describes a new species of dragonfly, Protosticta armageddonensis, from the Western Ghats of India, distinguishing it from three similar species through morphological features.

Spatial transcriptomics analysis of neoadjuvant cabozantinib and nivolumab in advanced hepatocellular carcinoma identifies independent mechanisms of resistance and recurrence

This study uses spatial transcriptomics to analyze HCC tumors treated with cabozantinib and nivolumab, identifying distinct immune and fibrotic mechanisms linked to response and recurrence.

Sniffer beetles: Odor imaging reveals congeneric herbivores identify their congeneric hostplants based on differential olfactory perceptions

The paper investigates how congeneric herbivorous beetles distinguish between closely related hostplants using odor blends, revealing differential olfactory perceptions and the importance of the volatile matrix.

High Density Domain-Focused CRISPR Screens Reveal Novel Epigenetic Regulators of HOX/MEIS Activation in Acute Myeloid Leukemia

The paper identifies SGF29 as a novel chromatin regulator of MEIS1 and AML oncogenes, showing its role in leukemogenesis and potential as a drug target.

Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile

This study identifies a mutation in C. difficile that causes metronidazole resistance and links it to fluoroquinolone resistance, contributing to the spread of drug-resistant strains.

Structure and Epitope of a Neutralizing Monoclonal Antibody that Targets the Stem Helix of β Coronaviruses

This paper determines the crystal structure of a broadly neutralizing antibody targeting the stem helix of coronaviruses and elucidates its mechanism of neutralization.

PanIN and CAF Transitions in Pancreatic Carcinogenesis Revealed with Spatial Data Integration

This paper develops a new protocol for spatial transcriptomics analysis of FFPE PanIN specimens and integrates it with imaging and scRNA-seq to study the progression from PanIN to PDAC.

Quantifying the movement, behavior, and environmental context of group-living animals using drones and computer vision

This paper introduces a system using drones and computer vision to track animal movement, posture, and environmental context in natural settings with high spatiotemporal resolution.

Chemical ecology of Himalayan eggplant variety's antixenosis: Identification of geraniol as an oviposition deterrent against the eggplant shoot and fruit borer

The paper identifies geraniol as an oviposition deterrent in the Himalayan eggplant variety RL22 against the shoot and fruit borer, reducing the need for harmful pesticides.

Potent universal-coronavirus therapeutic activity mediated by direct respiratory administration of a Spike S2 domain-specific human neutralizing monoclonal antibody

This study identifies a potent universal coronavirus neutralizing monoclonal antibody, 1249A8, effective against multiple variants and demonstrating therapeutic activity through intranasal administration.

The Ferrous Iron Transporter FeoB1 is Essential for Clostridioides difficile Toxin Production and Pathogenesis in Mice

This study shows that FeoB1 is critical for C. difficile toxin production and virulence, suggesting it as a therapeutic target for CDI.

Transcriptomic response of Cinachyrella cf. cavernosa sponges to spatial competition

This study uses transcriptomics to analyze how Cinachyrella cf. cavernosa sponges respond to spatial competition with Zoanthus sansibaricus and Dictyota ciliolata, finding increased cellular respiration and stress responses.

Epitope classification and RBD binding properties of neutralizing antibodies against SARS-CoV-2 variants of concern

This study classifies NAb epitopes against SARS-CoV-2 RBD and evaluates how variants affect NAb and ACE2 binding, identifying key mutations that impact neutralization and infectivity.

HIV-1 uncoating occurs via a series of rapid biomechanical changes in the core related to individual stages of reverse transcription

This study uses atomic force microscopy to observe stiffness changes in HIV-1 cores during reverse transcription, linking mechanical spikes to specific stages of the process.

RNF5 Regulation of RBBP4 Defines Acute Myeloid Leukemia Growth and Susceptibility to Histone Deacetylase Inhibitors

This study shows RNF5 promotes AML growth by regulating RBBP4 and epigenetic pathways, and its inhibition enhances sensitivity to HDAC inhibitors, suggesting it as a therapeutic target and biomarker.

Therapeutic activity of an inhaled potent SARS-CoV-2 neutralizing human monoclonal antibody in hamsters

This study evaluates an inhaled monoclonal antibody against SARS-CoV-2 in hamsters, showing reduced viral burden and lung pathology with low-dose inhalation.

A JAK/STAT-Mediated Inflammatory Signaling Cascade Drives Oncogenesis In AF10-Rearranged AML

This study identifies JAK1 as a therapeutic target in AF10-rearranged AML by showing its role in JAK/STAT-mediated inflammatory signaling and oncogenesis.

Comparative analysis of genome-wide DNA methylation identifies patterns that associate with conserved transcriptional programs in osteosarcoma

This study identifies DNA methylation patterns in human and canine osteosarcoma samples that correlate with conserved transcriptional programs and tumor states, not cell composition.

Chromosomal Resistance to Metronidazole in Clostridioides difficile can be Mediated By Epistasis Between Iron Homeostasis and Oxidoreductases

This study identifies multi-genetic mechanisms of metronidazole resistance in C. difficile, showing epistasis between iron homeostasis and oxidoreductases.

The Dynamic Landscape of Transcription Initiation in Yeast Mitochondria

This study investigates the conformational dynamics of yeast mitochondrial transcription initiation using single-molecule techniques, revealing dynamic transitions and backtracking behavior.

Integrated computational and experimental identification of p53, KRAS and VHL mutant selection associated with CRISPR-Cas9 editing

The paper identifies p53, KRAS, and VHL mutations as being selected during CRISPR-Cas9 editing through computational and experimental analysis.

Phylogenetic Tree-based Pipeline for Uncovering Mutational Patterns during Influenza Virus Evolution

The paper introduces a phylogenetic tree-based pipeline to identify statistically significant mutations in influenza virus evolution, applied to H3N2 HA sequences over 50 years.

Acute Myeloid Leukemia Driven by the CALM-AF10 Fusion Gene is Dependent on BMI1

This study shows that BMI1 is overexpressed in CALM-AF10-positive leukemias and that inhibiting BMI1 with PTC209 or PTC596 reduces leukemia growth and prolongs survival.

Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys

This study shows that preexisting antibodies can prevent congenital cytomegalovirus infection in monkeys by blocking placental transmission.