A broad matrix metalloproteinase inhibitor with designed loop extension exhibits ultrahigh specificity for MMP-14
A. Bonadio, B. Wenig, A. Hockla, E. S. Radisky, J. M. Shifman
The paper designs a broad MMP inhibitor with a loop extension that shows high specificity for MMP-14 over MMP-3, achieving 7500-fold improved specificity compared to wild-type N-TIMP2.
bioRxiv · Dec 29, 2022 · PreprintBiochemistry