Author

A. Bonadio

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

J. M. Shifman· 2 shared A. Hockla· 1 shared B. Wenig· 1 shared E. S. Radisky· 1 shared O. Kleifeld· 1 shared S. Oguche· 1 shared T. Lavy· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 12 mutual co-author links

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2 shared papersBiochemistry

J. M. Shifman

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2 papers

Recent·Most cited

Computational design of Matrix Metalloprotenaise-9 (MMP-9) resistant to auto-cleavage

A. Bonadio, S. Oguche, T. Lavy, O. Kleifeld, J. M. Shifman

The paper designs a stable MMP-9 variant resistant to auto-cleavage while maintaining enzyme activity, suitable for drug development and structural studies.

bioRxiv · Apr 11, 2023Biochemistry

A broad matrix metalloproteinase inhibitor with designed loop extension exhibits ultrahigh specificity for MMP-14

A. Bonadio, B. Wenig, A. Hockla, E. S. Radisky, J. M. Shifman

The paper designs a broad MMP inhibitor with a loop extension that shows high specificity for MMP-14 over MMP-3, achieving 7500-fold improved specificity compared to wild-type N-TIMP2.

bioRxiv · Dec 29, 2022 · PreprintBiochemistry