Author

A. Hockla

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

J. M. Shifman· 2 shared A. Alasonyalilar Demirer· 1 shared A. Bonadio· 1 shared B. Wenig· 1 shared E. Radisky· 1 shared E. S. Radisky· 1 shared J. A. Copland· 1 shared J. J. Gleba· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

J. M. Shifman

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Improving Circulation Half-Life of Therapeutic Candidate N-TIMP2 by Unfolded Peptide Extension

J. Shirian, A. Hockla, J. J. Gleba, M. Coban, N. Rotenberg, L. M. Strik, A. Alasonyalilar Demirer, M. L. Pawlush, J. A. Copland, E. Radisky, J. M. Shifman

This study extends the plasma half-life of N-TIMP2 by appending a PATylated tail, showing improved therapeutic potential in mice.

bioRxiv · Jun 27, 2024Biochemistry

A broad matrix metalloproteinase inhibitor with designed loop extension exhibits ultrahigh specificity for MMP-14

A. Bonadio, B. Wenig, A. Hockla, E. S. Radisky, J. M. Shifman

The paper designs a broad MMP inhibitor with a loop extension that shows high specificity for MMP-14 over MMP-3, achieving 7500-fold improved specificity compared to wild-type N-TIMP2.

bioRxiv · Dec 29, 2022 · PreprintBiochemistry