Author

J. M. Shifman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein design· 1 Assay:protein structure· 1

Frequent Co-Authors

E. S. Radisky· 3 shared A. Bonadio· 2 shared I. Cohen· 2 shared J. Shirian· 2 shared N. Papo· 2 shared A. Hockla· 1 shared B. Wenig· 1 shared M. Heyne· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersBiophysics

E. S. Radisky

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Author profile →

4 papers

Recent·Most cited

Computational design of Matrix Metalloprotenaise-9 (MMP-9) resistant to auto-cleavage

A. Bonadio, S. Oguche, T. Lavy, O. Kleifeld, J. M. Shifman

The paper designs a stable MMP-9 variant resistant to auto-cleavage while maintaining enzyme activity, suitable for drug development and structural studies.

bioRxiv · Apr 11, 2023Biochemistry

A broad matrix metalloproteinase inhibitor with designed loop extension exhibits ultrahigh specificity for MMP-14

A. Bonadio, B. Wenig, A. Hockla, E. S. Radisky, J. M. Shifman

The paper designs a broad MMP inhibitor with a loop extension that shows high specificity for MMP-14 over MMP-3, achieving 7500-fold improved specificity compared to wild-type N-TIMP2.

bioRxiv · Dec 29, 2022 · PreprintBiochemistry

Climbing up and down binding landscapes: a high-throughput study of mutational effects in homologous protein-protein complexes

M. Heyne, J. Shirian, I. Cohen, Y. Peleg, E. S. Radisky, N. Papo, J. M. Shifman

This study quantifies mutational effects on binding affinity in three homologous protease-inhibitor complexes, revealing distinct binding landscapes and epistasis patterns.

bioRxiv · Oct 14, 2020Biophysics

Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP-9 and MMP-14

J. Shirian, V. Arkadash, I. Cohen, T. Sapir, E. S. Radisky, N. Papo, J. M. Shifman

The paper engineers a specific inhibitor for MMP-9 and MMP-14 from a broad MMP inhibitor using computational design and yeast surface display, showing enhanced specificity and structural insights.

bioRxiv · Dec 31, 2017Biophysics