Natural product-mediated reaction hijacking mechanism validates Plasmodium aspartyl-tRNA synthetase as an antimalarial drug target
Nutpakal Ketprasit, Chia-Wei Tai, Vivek Kumar Sharma, M. Yogavel, Yogesh B. Khandokar, Xi Ye, Con Dogovski, David H. Hilko, Craig J. Morton, Anne-Sophie C. Braun, Michael G. Leeming, Bagale Siddharam, Gerald John Shami, Pushpangadan Indira Pradeepkumar, Santosh Panjikar, , Stanley C. Xie
This study identifies Plasmodium aspartyl-tRNA synthetase as an antimalarial target by showing how natural products inhibit protein translation through reaction hijacking.
PLoS Pathogens · Jul 8, 2025Peer-reviewedBiochemistry