Nanogram of Arg 1 Delivered by extracellular vesicles restore ARG1 activity in a mouse model of ARG1-D and improve lifespan.
Li‐En Hsieh, Mafalda Cacciottolo, Michael J. LeClaire, William H. Morrison, Bailey Murphy, Christy Lau, Kristi Elliott, Linda Marbán, Minghao Sun
This paper demonstrates that extracellular vesicles carrying ARG1 can restore enzyme activity and extend lifespan in a mouse model of ARG1-D.
bioRxiv · Sep 23, 2025 · PreprintGenetics