Mafalda Cacciottolo

This study shows ApoE isoforms influence antioxidant pathways differently across aging, with ApoE4 showing stronger transcriptional responses but less effective protein production, linking to neurodegenerative risk.

The paper shows chimpanzee ApoE isoforms increase neurite number but reduce neurite length compared to human ApoE isoforms, suggesting functional similarity to ApoE4.

This paper demonstrates that extracellular vesicles carrying ARG1 can restore enzyme activity and extend lifespan in a mouse model of ARG1-D.